Leukocyte Platelet Rich Fibrin

Leukoctye Platelet Rich Fibrin (L-PRF) is a by-product of blood (plasma) that is rich in platelets. Until now, its use has been confined to the hospital setting. This was due mainly to the cost of separating the platelets from the blood and the large amount of blood needed to produce a suitable quantity of platelets. New technology permits doctors to harvest and produce a sufficient quantity of platelets from only 55 cc of blood, which is drawn from the patient while they are having outpatient surgery.

Why All The Excitement About L-PRF?

L-PRF permits the body to take advantage of the normal healing pathways at a greatly accelerated rate. During the healing process, the body rushes many cells and cell-types to the wound in order to initiate the healing process. One of those cell types is platelets. Platelets perform many functions, including formation of a blood clot and release of growth factors (GF) into the wound. These growth factors; platelet derived growth factors (PDGF), transforming growth factor beta (TGF), and insulin-like growth factor (ILGF), function to assist the body in repairing itself by stimulating stem cells to regenerate new tissue. The more growth factors released and sequestered into the wound, the more stem cells are stimulated to produce new tissue. Thus, L-PRF permits the body to heal faster and more efficiently.

A subfamily of TGF, is bone morphogenic protein (BMP). BMP has been shown to induce the formation of new bone in research studies in both animals and humans. This is of great significance to the surgeon who places dental implants. By adding L-PRF, and BMP, to the implant site with bone substitute particles, the implant surgeon can now grow bone more predictably and faster than ever before.

L-PRF Has Many Clinical Applications

L-PRF can be used to aid Bone grafting for dental implants. This includes onlay and inlay grafts, sinus lift procedures, ridge augmentation procedures, closure of cleft and/or lip, and palate defects. It can also assist in repair of bone defects created by removal of teeth, or small cysts and repair of fistulas between the sinus cavity and mouth.

L-PRF Also Has Many Advantages

Safety: L-PRF is a by-product of the patient’s own blood, therefore, disease transmission is not an issue.

Convenience: L-PRF can be generated in the doctor’s office while the patient is undergoing an outpatient surgical procedure such as the placement of dental implants.

Faster healing: The supersaturation of the wound with L-PRF, and thus growth factors, produces an increase of tissue synthesis and faster tissue regeneration.

Cost effectiveness: Since L-PRF harvesting is done with only 55 cc of blood in the doctor’s office, the patient need not incur the expense of the harvesting procedure in hospital or at a blood bank.

Ease of use: L-PRF is easy to handle and actually improves the ease of application of bone substitute materials and bone grafting products by making them more gel-like.

Frequently Asked Questions About L-PRF

Is L-PRF safe? Yes. During the outpatient surgical procedure a small amount of your own blood is drawn out via the IV. This blood is then placed in the L-PRf centrifuge machine and spun down. In less than 15 minutes, the L-PRF is formed and ready to use.

Should L-PRF be used in all bone-grafting cases? Not always. In some cases, there is no need for L-PRF. However, in the majority of cases, application of L-PRF to the graft will increase the final amount of bone present, in addition to making the wound heal faster and more efficiently.

Will my insurance cover the costs? Unfortunately not. The cost of the L-PRF application (approximately $200) is paid by the patient.  It is significantly less expensive, easier to process and more effective than Platelet Rich Plasma (PRP)

Can L-PRF be used alone to stimulate bone formation? No. L-PRF must be mixed with either the patient’s own bone, a bone substitute material such as demineralized freeze-dried bone, or a synthetic bone product, such as BIO-OSS.

Are there any contraindications to L-PRF? Very few. Obviously, patients with bleeding disorders or hematologic diseases do not qualify for this in-office procedure. Check with your surgeon and/or primary care physician to determine if PRP is right for you.

Cortland Oral Surgery

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Overall my experience here was really good and i would come again. I will be recommending my friends and family here

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very good

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Overall experience was excellent

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Everyone was very pleasant and professional. When I called the office the next day a human actually answered.

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It is so good to have this office in Cortland!

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Every body was friendly and informative

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Everything that I encountered from the first time talking to the staff on the phone was wonderful. Everyone is very pleasant and friendly. The dentist was calming. I have to say it also helped that the room was painted in a very calming tone..not stark white which helped me. The room, office and entire area was clean and welcoming.

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Dr. SanGiacomo and all the staff in the office helped me through what I considered a terrifying process. They made it bearable and as painless and quick as possible. I can't thank everyone enough for their kindness and patience.

- Laura H

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i had to have a tooth extraction for my rear molar. Needles are my worst fear but the Dr. was so good i didn't even feel it coming. His dental nurse was outstanding in every way-- from the time i sat down till the time i left she did her best to keep my mind off what was going to happen.

- Gordon I

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Filled out "History" online, no wait at the office. Procedure went fine. Highly recommend.

- Michael T

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A very tough extraction was easier with the kindness and professionalism of your staff. Thank you for making it as enjoyable as it could be!!

- Jennifer F

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what an outstanding experience.

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Even though I had a tooth extracted, the total experience was as pleasant as could be.....

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Thank you!

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Was really nervous about the visit, everyone there put me at ease . Much easier than anticipated. Would definitely recommend.

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Everyone I came in contact with were all great, friendly and knowledgeable. The Dr and my nurse were great keeping me informed and comfortable. Great staff!

- April C

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I would not hesitate to go back if I needed any further oral surgery. It took a bit to remove the tooth, but he remained 'calm' so I did also.

- Jean D

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Overall I had a very pleasant and painless experience. The doctor and the staff are amazing and willing to work with you for your specific needs, especially if you have an emergency. I will definitely be returning in the future for any more oral surgery needs!

- Luciarose B

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Excellent

- Paul D

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I have had many dentist visits over the years and dental work is not pleasant for the most part. Dr. SanGiacomo is one of the best and the staff is also at the top of the list. I do not live in Cortland and am not familiar with the area, but Dr. was recommended by my dentist and I am very appreciative of that. If I need more work done in the future, I know where to go. Also, the payment was less than the estimate given at time of appointment - always a pleasant surprise. I highly recommend Cortland Oral Surgery Center.

- Judy B

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