Leukocyte Platelet Rich Fibrin

Leukoctye Platelet Rich Fibrin (L-PRF) is a by-product of blood (plasma) that is rich in platelets. Until now, its use has been confined to the hospital setting. This was due mainly to the cost of separating the platelets from the blood and the large amount of blood needed to produce a suitable quantity of platelets. New technology permits doctors to harvest and produce a sufficient quantity of platelets from only 55 cc of blood, which is drawn from the patient while they are having outpatient surgery.

Why All The Excitement About L-PRF?

L-PRF permits the body to take advantage of the normal healing pathways at a greatly accelerated rate. During the healing process, the body rushes many cells and cell-types to the wound in order to initiate the healing process. One of those cell types is platelets. Platelets perform many functions, including formation of a blood clot and release of growth factors (GF) into the wound. These growth factors; platelet derived growth factors (PDGF), transforming growth factor beta (TGF), and insulin-like growth factor (ILGF), function to assist the body in repairing itself by stimulating stem cells to regenerate new tissue. The more growth factors released and sequestered into the wound, the more stem cells are stimulated to produce new tissue. Thus, L-PRF permits the body to heal faster and more efficiently.

A subfamily of TGF, is bone morphogenic protein (BMP). BMP has been shown to induce the formation of new bone in research studies in both animals and humans. This is of great significance to the surgeon who places dental implants. By adding L-PRF, and BMP, to the implant site with bone substitute particles, the implant surgeon can now grow bone more predictably and faster than ever before.

L-PRF Has Many Clinical Applications

L-PRF can be used to aid Bone grafting for dental implants. This includes onlay and inlay grafts, sinus lift procedures, ridge augmentation procedures, closure of cleft and/or lip, and palate defects. It can also assist in repair of bone defects created by removal of teeth, or small cysts and repair of fistulas between the sinus cavity and mouth.

L-PRF Also Has Many Advantages

Safety: L-PRF is a by-product of the patient’s own blood, therefore, disease transmission is not an issue.

Convenience: L-PRF can be generated in the doctor’s office while the patient is undergoing an outpatient surgical procedure such as the placement of dental implants.

Faster healing: The supersaturation of the wound with L-PRF, and thus growth factors, produces an increase of tissue synthesis and faster tissue regeneration.

Cost effectiveness: Since L-PRF harvesting is done with only 55 cc of blood in the doctor’s office, the patient need not incur the expense of the harvesting procedure in hospital or at a blood bank.

Ease of use: L-PRF is easy to handle and actually improves the ease of application of bone substitute materials and bone grafting products by making them more gel-like.

Frequently Asked Questions About L-PRF

Is L-PRF safe? Yes. During the outpatient surgical procedure a small amount of your own blood is drawn out via the IV. This blood is then placed in the L-PRf centrifuge machine and spun down. In less than 15 minutes, the L-PRF is formed and ready to use.

Should L-PRF be used in all bone-grafting cases? Not always. In some cases, there is no need for L-PRF. However, in the majority of cases, application of L-PRF to the graft will increase the final amount of bone present, in addition to making the wound heal faster and more efficiently.

Will my insurance cover the costs? Unfortunately not. The cost of the L-PRF application (approximately $200) is paid by the patient.  It is significantly less expensive, easier to process and more effective than Platelet Rich Plasma (PRP)

Can L-PRF be used alone to stimulate bone formation? No. L-PRF must be mixed with either the patient’s own bone, a bone substitute material such as demineralized freeze-dried bone, or a synthetic bone product, such as BIO-OSS.

Are there any contraindications to L-PRF? Very few. Obviously, patients with bleeding disorders or hematologic diseases do not qualify for this in-office procedure. Check with your surgeon and/or primary care physician to determine if PRP is right for you.

Cortland Oral Surgery

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Upon call to have a tooth extracted I received a appointment that week and a time that worked for me. I used the on line site to fill out the paper work so to speed up everything upon my arrival. The dr. and his assistant made me feel comfortable answered all my question and kept informed all through the procedure. After the procedure the assistant went over what I should expected and do now that the tooth was removed. I also received a hand out what she had gone over and said if I had any questions to call. The over all experience went smooth and the Dr. and staff were great.

- James L. s

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I would and will recommend you to anyone needing an oral surgeon.

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I was extremely happy with my experience in your office. Dr. SanGiacomo and his staff were excellent in terms of efficiency, courtesy and kindness. The procedure was flawless and pain free. I was expecting to awake the next day in pain, yet I was surprised to wake with little to no pain and no need to take any pain medication. Thank you all. Paul

- Paul S

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It was a great experience! Nobody likes the dentist but this office really made it comfortable, easy, and fast! The doctor/dentist was GREAT!!

- Jaffa B

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The visit was Great! When I called the day before and made appt. It was for 3:30 the next day and after filling out information on line for my appt. The receptionist called me back and was able to get me in that next morning at 8:30 instead! I was in alot of pain and my face was swellon. I was scared and the Dr was joking around with me and it helped me loosen up! Thank you for that!!

- Jennifer S

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I think I said it all love the quick service !!

- Howard C

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Doctor and staff was great

- Thoma T

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It was recommended by my dentist to have one of my wisdom teeth removed to avoid complications in the future. They recommended Dr. SanGiacomo. After examination of my teeth, he carefully explained why there was no reason to remove two perfectly fine wisdom teeth at this time. I was very impressed by his professionalism and integrity (and at the same time very relieved).

- Anonymous

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no problems, good at his job, laughed even... lol

- Meghan V

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It was an awesome experience.

- Sheila G

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Fantastic service

- melvin b

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Very friendly staff and doctor that helped put me at ease and answered my questions .

- Anna F

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Scheduling was fast! The front office staff were very friendly. I did not have to wait! The dental assistant was so very nice and made me feel comfortable. Dr. SanGiacomo was welcoming and very friendly. This was probably the best visit to the dentist I have ever experienced! Thank you!

- Deb B

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Awesome services very caring

- Vi S

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If you have to have a tooth extracted, this is a great place day to have it done - everyone was both professional and friendly and Dr. SanGiacomo’s skill and experience along with his ability to clearly explain the process gave me confidence that all would be well. Thank you!!!

- Kathleen G

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I was totally pleased. It is so good to be able to feel so confident in a medical professional.Keep it up!!!!!

- Antonia H

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I wrote a review. Debbie is wonderful and so efficient in making all the emergency arrangements. The Dentist was excellent!

- Robin G

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The Doctor there is the best and the staff super nice and efficient. Dental visits involving a significant procedure have always made me uncomfortable to say the least. My first visit was several years ago and I was amazed how great the Doctor and staff was. On my second recent visit I was very comfortable going because I knew I was in the best hands for the procedure and again very impressed with their professional work.

- MIKE K

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Great experience! Friendly staff.

- Theresa E

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Not sure if my previous review was received so have done a second one. Walked in after being referred by my dentist to get information on tooth extraction. Worked out that they could take me in that afternoon. With less time to worry, all the staff were professional, courteous and very calming. The doctor walked me through the procedure to extract a tooth and put my nerves at ease. Would recommend them to anyone, very pleased. Thank you to all.

- Marlene R

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