Leukocyte Platelet Rich Fibrin

Leukoctye Platelet Rich Fibrin (L-PRF) is a by-product of blood (plasma) that is rich in platelets. Until now, its use has been confined to the hospital setting. This was due mainly to the cost of separating the platelets from the blood and the large amount of blood needed to produce a suitable quantity of platelets. New technology permits doctors to harvest and produce a sufficient quantity of platelets from only 55 cc of blood, which is drawn from the patient while they are having outpatient surgery.

Why All The Excitement About L-PRF?

L-PRF permits the body to take advantage of the normal healing pathways at a greatly accelerated rate. During the healing process, the body rushes many cells and cell-types to the wound in order to initiate the healing process. One of those cell types is platelets. Platelets perform many functions, including formation of a blood clot and release of growth factors (GF) into the wound. These growth factors; platelet derived growth factors (PDGF), transforming growth factor beta (TGF), and insulin-like growth factor (ILGF), function to assist the body in repairing itself by stimulating stem cells to regenerate new tissue. The more growth factors released and sequestered into the wound, the more stem cells are stimulated to produce new tissue. Thus, L-PRF permits the body to heal faster and more efficiently.

A subfamily of TGF, is bone morphogenic protein (BMP). BMP has been shown to induce the formation of new bone in research studies in both animals and humans. This is of great significance to the surgeon who places dental implants. By adding L-PRF, and BMP, to the implant site with bone substitute particles, the implant surgeon can now grow bone more predictably and faster than ever before.

L-PRF Has Many Clinical Applications

L-PRF can be used to aid Bone grafting for dental implants. This includes onlay and inlay grafts, sinus lift procedures, ridge augmentation procedures, closure of cleft and/or lip, and palate defects. It can also assist in repair of bone defects created by removal of teeth, or small cysts and repair of fistulas between the sinus cavity and mouth.

L-PRF Also Has Many Advantages

Safety: L-PRF is a by-product of the patient’s own blood, therefore, disease transmission is not an issue.

Convenience: L-PRF can be generated in the doctor’s office while the patient is undergoing an outpatient surgical procedure such as the placement of dental implants.

Faster healing: The supersaturation of the wound with L-PRF, and thus growth factors, produces an increase of tissue synthesis and faster tissue regeneration.

Cost effectiveness: Since L-PRF harvesting is done with only 55 cc of blood in the doctor’s office, the patient need not incur the expense of the harvesting procedure in hospital or at a blood bank.

Ease of use: L-PRF is easy to handle and actually improves the ease of application of bone substitute materials and bone grafting products by making them more gel-like.

Frequently Asked Questions About L-PRF

Is L-PRF safe? Yes. During the outpatient surgical procedure a small amount of your own blood is drawn out via the IV. This blood is then placed in the L-PRf centrifuge machine and spun down. In less than 15 minutes, the L-PRF is formed and ready to use.

Should L-PRF be used in all bone-grafting cases? Not always. In some cases, there is no need for L-PRF. However, in the majority of cases, application of L-PRF to the graft will increase the final amount of bone present, in addition to making the wound heal faster and more efficiently.

Will my insurance cover the costs? Unfortunately not. The cost of the L-PRF application (approximately $200) is paid by the patient.  It is significantly less expensive, easier to process and more effective than Platelet Rich Plasma (PRP)

Can L-PRF be used alone to stimulate bone formation? No. L-PRF must be mixed with either the patient’s own bone, a bone substitute material such as demineralized freeze-dried bone, or a synthetic bone product, such as BIO-OSS.

Are there any contraindications to L-PRF? Very few. Obviously, patients with bleeding disorders or hematologic diseases do not qualify for this in-office procedure. Check with your surgeon and/or primary care physician to determine if PRP is right for you.

Cortland Oral Surgery

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This was our first visit to the office and considering what is happening with the pandemic, we felt very comfortable. The staff and doctor were very nice. The ease of appointment, paperwork and care after was great!!

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Excellent patient service, very friendly staff, quick execution of the procedure and no pain!

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I highly recommend Cortland Oral Care.

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Dr. SanGiacomo was very calming and explained things well. Has a great personality.

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Good visit, quick and painless.

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Such a great office! I was in so much pain and everyone that was there was really kind and helpful-from scheduling my appointment(that I was able to move ahead of time due to a cancellation), to making sure I was warm, comfy, and properly numbed before my procedure. Dr. SanGiacomo was very skilled and knowledgeable, and my procedure went by smoothly and quickly (the pain was to be expected). Overall everything from beginning to end was really easy, the pricing was very fair (especially for someone like me with no dental insurance) and I will absolutely continue to come here and recommend this place to everyone I know.

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It was very fast, I was in and out! And the recovery is amazing, wouldn’t want to go to another oral sergeant!

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Highly recommend!! Service was the best !!!!

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I couldn't have been more pleased with the my visit and the procedure done. The staff and doctor helped me to feel at ease during a possibly stressful procedure

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Fast, easy, overall great experience

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The doctor and staff were really great.

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I was so nervous but everybody made me feel at ease. The procedure was no problem and I have not had any pain and not needEd any meds. Thank you.

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Doctor SanGiacomo (spelling?) is the best dentist/oral surgeon when comes to extractions. He has a gentle touch and when he administers the pain shot he does so carefully. Every other Dentist I've gone to had been more of stabber.

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Both of my children have had their wisdom teeth out and everyone was very helpful and kind.

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Thank you so much. Was a pleasure doing business with you.

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Entire office staff were wonderful once again. Both of my daughters have had wisdom teeth removal. The doctor, nurses and front office staff are very kind, caring and amazing!

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I highly recommend Cortland Oral Surgery Center and Dr. SanGiacomo. He made a stressful situation comfortable by his manner and the only pain I felt was the Novocain needle.

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So thankful for everyone at the office!

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Appointment time 3:30, done and gone by 4:05. This is pretty great too because of the condition my tooth was in. Doc did awesome, staff was friendly.

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The extraction site is healing nicely after 24 hours, with little swelling or pain. Thank you.

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