Leukocyte Platelet Rich Fibrin

Leukoctye Platelet Rich Fibrin (L-PRF) is a by-product of blood (plasma) that is rich in platelets. Until now, its use has been confined to the hospital setting. This was due mainly to the cost of separating the platelets from the blood and the large amount of blood needed to produce a suitable quantity of platelets. New technology permits doctors to harvest and produce a sufficient quantity of platelets from only 55 cc of blood, which is drawn from the patient while they are having outpatient surgery.

Why All The Excitement About L-PRF?

L-PRF permits the body to take advantage of the normal healing pathways at a greatly accelerated rate. During the healing process, the body rushes many cells and cell-types to the wound in order to initiate the healing process. One of those cell types is platelets. Platelets perform many functions, including formation of a blood clot and release of growth factors (GF) into the wound. These growth factors; platelet derived growth factors (PDGF), transforming growth factor beta (TGF), and insulin-like growth factor (ILGF), function to assist the body in repairing itself by stimulating stem cells to regenerate new tissue. The more growth factors released and sequestered into the wound, the more stem cells are stimulated to produce new tissue. Thus, L-PRF permits the body to heal faster and more efficiently.

A subfamily of TGF, is bone morphogenic protein (BMP). BMP has been shown to induce the formation of new bone in research studies in both animals and humans. This is of great significance to the surgeon who places dental implants. By adding L-PRF, and BMP, to the implant site with bone substitute particles, the implant surgeon can now grow bone more predictably and faster than ever before.

L-PRF Has Many Clinical Applications

L-PRF can be used to aid Bone grafting for dental implants. This includes onlay and inlay grafts, sinus lift procedures, ridge augmentation procedures, closure of cleft and/or lip, and palate defects. It can also assist in repair of bone defects created by removal of teeth, or small cysts and repair of fistulas between the sinus cavity and mouth.

L-PRF Also Has Many Advantages

Safety: L-PRF is a by-product of the patient’s own blood, therefore, disease transmission is not an issue.

Convenience: L-PRF can be generated in the doctor’s office while the patient is undergoing an outpatient surgical procedure such as the placement of dental implants.

Faster healing: The supersaturation of the wound with L-PRF, and thus growth factors, produces an increase of tissue synthesis and faster tissue regeneration.

Cost effectiveness: Since L-PRF harvesting is done with only 55 cc of blood in the doctor’s office, the patient need not incur the expense of the harvesting procedure in hospital or at a blood bank.

Ease of use: L-PRF is easy to handle and actually improves the ease of application of bone substitute materials and bone grafting products by making them more gel-like.

Frequently Asked Questions About L-PRF

Is L-PRF safe? Yes. During the outpatient surgical procedure a small amount of your own blood is drawn out via the IV. This blood is then placed in the L-PRf centrifuge machine and spun down. In less than 15 minutes, the L-PRF is formed and ready to use.

Should L-PRF be used in all bone-grafting cases? Not always. In some cases, there is no need for L-PRF. However, in the majority of cases, application of L-PRF to the graft will increase the final amount of bone present, in addition to making the wound heal faster and more efficiently.

Will my insurance cover the costs? Unfortunately not. The cost of the L-PRF application (approximately $200) is paid by the patient.  It is significantly less expensive, easier to process and more effective than Platelet Rich Plasma (PRP)

Can L-PRF be used alone to stimulate bone formation? No. L-PRF must be mixed with either the patient’s own bone, a bone substitute material such as demineralized freeze-dried bone, or a synthetic bone product, such as BIO-OSS.

Are there any contraindications to L-PRF? Very few. Obviously, patients with bleeding disorders or hematologic diseases do not qualify for this in-office procedure. Check with your surgeon and/or primary care physician to determine if PRP is right for you.

Cortland Oral Surgery

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This dentist is absolutley amazing. The staff we great. They all left a great lasting impression. My 15 year old daughter loved them too.

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The relaxing atmosphere with friendly people here made getting my tooth pulled an easy experience. I went home with all the info I needed, and by the morning I wouldn't have known it was pulled. Thank you!

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Very smooth operation. Staff was attentive and thorough. Noone likes Oral Surgery, but overall it was a great experience!

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my daughter was very nervous about getting her wisdom teeth out. she ended up having a great experience

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I have to say you all are so wonderful! Your kindness was above anything I expected. I need to thank Dr. SanGiacomo for taking me on as a patient. He was wonderful at explaining everything and he was gentle extracting the tooth. I love the nice little book of instruction he gave me. All I can say if anyone who has a tooth extracted and they read the book and do what it says you will have no problem. I have no pain medication to take and I have had no pain or swelling. Thank you Dr. SanGiacomo and staff for the wonderful care you gave me!

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I was very nervous about having all 4 of my wisdom teeth extracted. I definitely thought the worst. The procedure was quick and comfortable. My daughter will need her wisdoms out soon and we will be coming back.

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Literally the most supportive team I have ever had work on my teeth. From Dr. SanGiacomo to the receptionist, they treated me with the highest level of expertise and kindness. I was scared because it was a large wisdom tooth, but 14 hours after surgery and I am feeling very little pain.

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Very friendly and caring. Made me feel very comfortable.

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Excellent dentist with good bedside manner. His humor and joking helped ease my anxiety about the procedure.

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Although I had a difficult tooth to extract, doctor handled the situation well. No problems or pain after “sleeping on it”.

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Very smooth for a nervous patient. Great job, staff and. Doc.

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i was surprised with how at ease they made me feel

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very good

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The staff was very pleasant and good at their work. The doctor was very caring and removed my tooth quickly and with very little pain. I am very happy with the outcome.

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Great job team!

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Very easy procedure...great doctor and nurse!

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I think it is a good dental center, staffs and doctor here are friendly.

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