Leukocyte Platelet Rich Fibrin

Leukoctye Platelet Rich Fibrin (L-PRF) is a by-product of blood (plasma) that is rich in platelets. Until now, its use has been confined to the hospital setting. This was due mainly to the cost of separating the platelets from the blood and the large amount of blood needed to produce a suitable quantity of platelets. New technology permits doctors to harvest and produce a sufficient quantity of platelets from only 55 cc of blood, which is drawn from the patient while they are having outpatient surgery.

Why All The Excitement About L-PRF?

L-PRF permits the body to take advantage of the normal healing pathways at a greatly accelerated rate. During the healing process, the body rushes many cells and cell-types to the wound in order to initiate the healing process. One of those cell types is platelets. Platelets perform many functions, including formation of a blood clot and release of growth factors (GF) into the wound. These growth factors; platelet derived growth factors (PDGF), transforming growth factor beta (TGF), and insulin-like growth factor (ILGF), function to assist the body in repairing itself by stimulating stem cells to regenerate new tissue. The more growth factors released and sequestered into the wound, the more stem cells are stimulated to produce new tissue. Thus, L-PRF permits the body to heal faster and more efficiently.

A subfamily of TGF, is bone morphogenic protein (BMP). BMP has been shown to induce the formation of new bone in research studies in both animals and humans. This is of great significance to the surgeon who places dental implants. By adding L-PRF, and BMP, to the implant site with bone substitute particles, the implant surgeon can now grow bone more predictably and faster than ever before.

L-PRF Has Many Clinical Applications

L-PRF can be used to aid Bone grafting for dental implants. This includes onlay and inlay grafts, sinus lift procedures, ridge augmentation procedures, closure of cleft and/or lip, and palate defects. It can also assist in repair of bone defects created by removal of teeth, or small cysts and repair of fistulas between the sinus cavity and mouth.

L-PRF Also Has Many Advantages

Safety: L-PRF is a by-product of the patient’s own blood, therefore, disease transmission is not an issue.

Convenience: L-PRF can be generated in the doctor’s office while the patient is undergoing an outpatient surgical procedure such as the placement of dental implants.

Faster healing: The supersaturation of the wound with L-PRF, and thus growth factors, produces an increase of tissue synthesis and faster tissue regeneration.

Cost effectiveness: Since L-PRF harvesting is done with only 55 cc of blood in the doctor’s office, the patient need not incur the expense of the harvesting procedure in hospital or at a blood bank.

Ease of use: L-PRF is easy to handle and actually improves the ease of application of bone substitute materials and bone grafting products by making them more gel-like.

Frequently Asked Questions About L-PRF

Is L-PRF safe? Yes. During the outpatient surgical procedure a small amount of your own blood is drawn out via the IV. This blood is then placed in the L-PRf centrifuge machine and spun down. In less than 15 minutes, the L-PRF is formed and ready to use.

Should L-PRF be used in all bone-grafting cases? Not always. In some cases, there is no need for L-PRF. However, in the majority of cases, application of L-PRF to the graft will increase the final amount of bone present, in addition to making the wound heal faster and more efficiently.

Will my insurance cover the costs? Unfortunately not. The cost of the L-PRF application (approximately $200) is paid by the patient.  It is significantly less expensive, easier to process and more effective than Platelet Rich Plasma (PRP)

Can L-PRF be used alone to stimulate bone formation? No. L-PRF must be mixed with either the patient’s own bone, a bone substitute material such as demineralized freeze-dried bone, or a synthetic bone product, such as BIO-OSS.

Are there any contraindications to L-PRF? Very few. Obviously, patients with bleeding disorders or hematologic diseases do not qualify for this in-office procedure. Check with your surgeon and/or primary care physician to determine if PRP is right for you.

Cortland Oral Surgery

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I was very anxious about getting these extractions. The staff were very encouraging and put me at ease. Dr SanGiacomo was very professional and has a great sense of humor,which I really appreciated!

- Patricia M

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Everything went very smooth, the tooth extraction was actually easier than I thought

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Had a bad tooth ache, called and got me right in. Great service and great result as I have not had any issues. Staff was very friendly and helpful. Doc is the best.

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Great place and amazing staff

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Very efficient, I felt very comfortable.

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friendly staff that makes you feel very comfortable. made sure i was not in pain during the procedure. explained everything clearly

- tim f

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I had had such terrible experiences in the past with getting a tooth pulled and I stated that right off the bat. From the first person I told that to....to the Doctor himself.....they all eased my worries and were very confident that I would have a different experience! And I did! Would recommend them 100% to anyone from now on! It's awful to have to have a tooth pulled to begin with and this Doctor combined with his staff were outstanding in my mind!

- Sue S

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The staff was very friendly and attentive. The doctor has a down to earth attitude which helps put you at ease.

- Lee E

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Very friendly and great place to have oral surgery

- Keith D

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Our experience was great. My son had all 4 wisdom teeth (all impacted) removed. The staff was friendly and informative. The doctor was laid back and funny, which put us at ease! Thank you all for a good experience

- Anonymous

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Great service and the explanation of the insurance was top notch.

- Phil B

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The doctor and staff made me feel more at ease. Infomation was very forth coming and the doctor kept me informed of what he was doing at all times.

- Donna O

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Couldn’t have asked for a better experience. Procedure went well and I was comfortable and all my questions were answered. Post surgery care was explained in depth and given a pamphlet to refer to at home.

- Barbara A

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This was the 4th time a family member needed widom teeth removed and everything has gone smoothly with all the procedures.

- Peggy D

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For a not so pleasant procedure, they made it more than tolerable. The staff was so supportive and the care was excellent!

- Courtney S

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The entire staff was courteous and helpful. Any concerns I had were addressed promptly.

- Celeste S

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great service

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they did a great job

- lucas b

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Very friendly staff and dentist, nice establishment

- Yvonne A

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Hope I will not need any more extractions - prior to this one it has been about 46 years since I had to have a tooth extracted - but if I should I will definitely return to this office.

- Linda M

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