Leukocyte Platelet Rich Fibrin

Leukoctye Platelet Rich Fibrin (L-PRF) is a by-product of blood (plasma) that is rich in platelets. Until now, its use has been confined to the hospital setting. This was due mainly to the cost of separating the platelets from the blood and the large amount of blood needed to produce a suitable quantity of platelets. New technology permits doctors to harvest and produce a sufficient quantity of platelets from only 55 cc of blood, which is drawn from the patient while they are having outpatient surgery.

Why All The Excitement About L-PRF?

L-PRF permits the body to take advantage of the normal healing pathways at a greatly accelerated rate. During the healing process, the body rushes many cells and cell-types to the wound in order to initiate the healing process. One of those cell types is platelets. Platelets perform many functions, including formation of a blood clot and release of growth factors (GF) into the wound. These growth factors; platelet derived growth factors (PDGF), transforming growth factor beta (TGF), and insulin-like growth factor (ILGF), function to assist the body in repairing itself by stimulating stem cells to regenerate new tissue. The more growth factors released and sequestered into the wound, the more stem cells are stimulated to produce new tissue. Thus, L-PRF permits the body to heal faster and more efficiently.

A subfamily of TGF, is bone morphogenic protein (BMP). BMP has been shown to induce the formation of new bone in research studies in both animals and humans. This is of great significance to the surgeon who places dental implants. By adding L-PRF, and BMP, to the implant site with bone substitute particles, the implant surgeon can now grow bone more predictably and faster than ever before.

L-PRF Has Many Clinical Applications

L-PRF can be used to aid Bone grafting for dental implants. This includes onlay and inlay grafts, sinus lift procedures, ridge augmentation procedures, closure of cleft and/or lip, and palate defects. It can also assist in repair of bone defects created by removal of teeth, or small cysts and repair of fistulas between the sinus cavity and mouth.

L-PRF Also Has Many Advantages

Safety: L-PRF is a by-product of the patient’s own blood, therefore, disease transmission is not an issue.

Convenience: L-PRF can be generated in the doctor’s office while the patient is undergoing an outpatient surgical procedure such as the placement of dental implants.

Faster healing: The supersaturation of the wound with L-PRF, and thus growth factors, produces an increase of tissue synthesis and faster tissue regeneration.

Cost effectiveness: Since L-PRF harvesting is done with only 55 cc of blood in the doctor’s office, the patient need not incur the expense of the harvesting procedure in hospital or at a blood bank.

Ease of use: L-PRF is easy to handle and actually improves the ease of application of bone substitute materials and bone grafting products by making them more gel-like.

Frequently Asked Questions About L-PRF

Is L-PRF safe? Yes. During the outpatient surgical procedure a small amount of your own blood is drawn out via the IV. This blood is then placed in the L-PRf centrifuge machine and spun down. In less than 15 minutes, the L-PRF is formed and ready to use.

Should L-PRF be used in all bone-grafting cases? Not always. In some cases, there is no need for L-PRF. However, in the majority of cases, application of L-PRF to the graft will increase the final amount of bone present, in addition to making the wound heal faster and more efficiently.

Will my insurance cover the costs? Unfortunately not. The cost of the L-PRF application (approximately $200) is paid by the patient.  It is significantly less expensive, easier to process and more effective than Platelet Rich Plasma (PRP)

Can L-PRF be used alone to stimulate bone formation? No. L-PRF must be mixed with either the patient’s own bone, a bone substitute material such as demineralized freeze-dried bone, or a synthetic bone product, such as BIO-OSS.

Are there any contraindications to L-PRF? Very few. Obviously, patients with bleeding disorders or hematologic diseases do not qualify for this in-office procedure. Check with your surgeon and/or primary care physician to determine if PRP is right for you.

Cortland Oral Surgery

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I was surprised at the lack of pain. I kept waiting for the pain to kick in but it never did. I did not take any medication for pain. Not so much as an aspirin. Excellent work and excellent staff.

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Very professional and friendly . Doctor was on time and didn't have to wait. Was in and out, less than 30 minutes. I wiould go there again , if I need futher work.

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Having a tooth pulled is bad enough but I had just the root to be pulled.. little scary..ok alot scary but, this was the best experience ever...everyone was very nice.Thank you very much for having so much compassion.

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I had a wisdom tooth extracted, process was quick and easy for me. Staff was great and the process went well. Very satisfied with the care I received.

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The entire staff was amazing. They rock

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For an extraction that no one wants to go through, Dr. S was very kind and quick in getting the procedure done.

- Teresa V

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The staff were are all extremely nice and helpful. Dr. SanGiacomo did great work and I would return in the future if I ever have a need. It was a pleasant experience for having a tooth pulled.

- Ashly D

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Would most definitely recommend.

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Easy to talk to, very personable.

- Wendy C

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Very professional, friendly staff and Dr. S makes conversation that helped make the process calm. You get an instruction booklet for after the process that is very helpful.

- Jerri A

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Very friendly and professional.

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The oral surgeon is WONDERFUL, very caring, and will do what it takes to make everything right for you.

- George C

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The staff is super nice and knowledgeable. The doctor is very efficient, the whole extraction took less than 30 minutes. I am very pleased with the service and the care I received.

- Divya G

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Difficult extraction was painless.

- Tom S

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Excellent Service and great care during procedure

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Excellent staff. Procedure was VERY fast and efficient.

- Stephanie C

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As one might expect I went into the implant process anxious about the amount of discomfort and pain that would be involved. This was from the drilling of the jawbone to the recuperation afterward. Now the following day I realize the anxiety was completely unfounded. Dr SanGiocomo's surgical process was efficient and completely without discomfort. He explained what he was going to do and it unfolded as he had felt it would. Returning home, once the novocaine wore off, I anticipated at least a few hours of discomfort mollified by doses of Ibuprofen. That negative anticipation was unwarranted as well. There was no post surgery discomfort at all. Seriously! By the end of the day I was ready to send Dr SanGiocomo and his assistants a box of chocolates, but I didn't want them to worry about cavities.

- Rick R

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Extraction was not as bad as I feared! Whole visit very efficient.

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