Leukocyte Platelet Rich Fibrin

Leukoctye Platelet Rich Fibrin (L-PRF) is a by-product of blood (plasma) that is rich in platelets. Until now, its use has been confined to the hospital setting. This was due mainly to the cost of separating the platelets from the blood and the large amount of blood needed to produce a suitable quantity of platelets. New technology permits doctors to harvest and produce a sufficient quantity of platelets from only 55 cc of blood, which is drawn from the patient while they are having outpatient surgery.

Why All The Excitement About L-PRF?

L-PRF permits the body to take advantage of the normal healing pathways at a greatly accelerated rate. During the healing process, the body rushes many cells and cell-types to the wound in order to initiate the healing process. One of those cell types is platelets. Platelets perform many functions, including formation of a blood clot and release of growth factors (GF) into the wound. These growth factors; platelet derived growth factors (PDGF), transforming growth factor beta (TGF), and insulin-like growth factor (ILGF), function to assist the body in repairing itself by stimulating stem cells to regenerate new tissue. The more growth factors released and sequestered into the wound, the more stem cells are stimulated to produce new tissue. Thus, L-PRF permits the body to heal faster and more efficiently.

A subfamily of TGF, is bone morphogenic protein (BMP). BMP has been shown to induce the formation of new bone in research studies in both animals and humans. This is of great significance to the surgeon who places dental implants. By adding L-PRF, and BMP, to the implant site with bone substitute particles, the implant surgeon can now grow bone more predictably and faster than ever before.

L-PRF Has Many Clinical Applications

L-PRF can be used to aid Bone grafting for dental implants. This includes onlay and inlay grafts, sinus lift procedures, ridge augmentation procedures, closure of cleft and/or lip, and palate defects. It can also assist in repair of bone defects created by removal of teeth, or small cysts and repair of fistulas between the sinus cavity and mouth.

L-PRF Also Has Many Advantages

Safety: L-PRF is a by-product of the patient’s own blood, therefore, disease transmission is not an issue.

Convenience: L-PRF can be generated in the doctor’s office while the patient is undergoing an outpatient surgical procedure such as the placement of dental implants.

Faster healing: The supersaturation of the wound with L-PRF, and thus growth factors, produces an increase of tissue synthesis and faster tissue regeneration.

Cost effectiveness: Since L-PRF harvesting is done with only 55 cc of blood in the doctor’s office, the patient need not incur the expense of the harvesting procedure in hospital or at a blood bank.

Ease of use: L-PRF is easy to handle and actually improves the ease of application of bone substitute materials and bone grafting products by making them more gel-like.

Frequently Asked Questions About L-PRF

Is L-PRF safe? Yes. During the outpatient surgical procedure a small amount of your own blood is drawn out via the IV. This blood is then placed in the L-PRf centrifuge machine and spun down. In less than 15 minutes, the L-PRF is formed and ready to use.

Should L-PRF be used in all bone-grafting cases? Not always. In some cases, there is no need for L-PRF. However, in the majority of cases, application of L-PRF to the graft will increase the final amount of bone present, in addition to making the wound heal faster and more efficiently.

Will my insurance cover the costs? Unfortunately not. The cost of the L-PRF application (approximately $200) is paid by the patient.  It is significantly less expensive, easier to process and more effective than Platelet Rich Plasma (PRP)

Can L-PRF be used alone to stimulate bone formation? No. L-PRF must be mixed with either the patient’s own bone, a bone substitute material such as demineralized freeze-dried bone, or a synthetic bone product, such as BIO-OSS.

Are there any contraindications to L-PRF? Very few. Obviously, patients with bleeding disorders or hematologic diseases do not qualify for this in-office procedure. Check with your surgeon and/or primary care physician to determine if PRP is right for you.

Cortland Oral Surgery

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Our Latest Patient Testimonial

As one might expect I went into the implant process anxious about the amount of discomfort and pain that would be involved. This was from the drilling of the jawbone to the recuperation afterward. Now the following day I realize the anxiety was completely unfounded. Dr SanGiocomo's surgical process was efficient and completely without discomfort. He explained what he was going to do and it unfolded as he had felt it would. Returning home, once the novocaine wore off, I anticipated at least a few hours of discomfort mollified by doses of Ibuprofen. That negative anticipation was unwarranted as well. There was no post surgery discomfort at all. Seriously! By the end of the day I was ready to send Dr SanGiocomo and his assistants a box of chocolates, but I didn't want them to worry about cavities.

- Rick R

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Extraction was not as bad as I feared! Whole visit very efficient.

- Palette F

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A+ I don't much like going to the dentist, let alone for an extraction. This was amazing.

- Mary S

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My first tooth extraction in years turned out to be quick and easy! I'll return here if there's ever a need beyond my regular dentist!

- A W

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excellent and explanations.

- Susan S

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A very positive appointment from the office receptionist through the procedure to check out. Will definitely recommend Dr. SanGiacomo.

- Barry B

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It’s obvious that you and your entire staff treat your patients the same way you would like to be treated if you were the patient. Thank you.

- Thomas J

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I could not be more satisfied. I needed two extractions but since it was my first experience I only scheduled for one. It went so smoothly with the doctor explaining everything I could expect. My confidence in the team was such that I went ahead and let them pull the second tooth. ( Which he did without hesitation ) My anxiety was fairly high and the team was very reassuring. Tooth extractions is not something I wish to do again, but if faced with need, I would definitely choose them. A huge thank you to the entre team. You made a very intimating experience much easier and you have definitely put the smile back on my face. Thank you. You rock!

- Lori C

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They did a very good job, I was very impressed. They got me in and out quickly, and they asked multiple times throughout my surgery if I was okay and how I was feeling.

- Leslie W

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Fast, efficient, personable, and reasonable fees. What more do you need?!

- Danial H

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Had a broken tooth and they got me right in, staff was very friendly and professional. Doctor Sangiacomo is a fantastic Dentist.

- Steve R

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Dr. SanGiacomo and his aide, Stephanie, showed me the X-ray of the tooth to be extracted, and Dr. SanGiacomo described what to expect during the procedure, which went smoothly. By the time I was ready to leave, the office staff (I'm sorry - I don't remember the individuals' names) had already submitted the bill for the procedure to my insurance company (so that I did not need to do so), and they had already sent antibiotic and pain-relief prescriptions to my pharmacy. Speaking of pain - I experienced hardly any. Before going to sleep, I took an Ibuprofen as a precaution. I slept well. I appreciate the personable and professional work of Dr. SanGiacomo and his staff. Sincerely, John S.

- John S

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Difficult extraction but handled with expertise.

- Andrew H

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Very satisfied. Everybody was very courteous and professional. Would return again if needed.

- Russell M

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I was so nervous during the whole procedure Dr SanGiacomo and his other staff member who was in the room with me made me feel comfortable they talked to me thru out the whole process and made me feel safe. The whole team was very friendly. Thank you so much.

- A G

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Everyone in the office was very friendly and I felt "at home" right away, although I had come into the office feeling very nervous. I am thankful that I had such a good experience.

- Sue C

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Great experience.

- Patricia J

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Super polite staff - sanGiacomo was brilliant; kept me informed for the entire 50 min surgery; keep tabs on if I was feeling any pain/discomfort; explained what my options were thoroughly, even when things took a turn. Everyone in the practice seems to be knowledgable, courteous, and efficient. Can't better than that.

- Caryln B

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Staff and Dr Sangiacomo are great! Took great care of me with me wisdom teeth extractions....highly recommend to anyone in need of oral surgery!

- Jacob H

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The Dr. and staff were very friendly and professional, even when my tooth gave them a rough time coming out.

- Bruce W

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