Leukocyte Platelet Rich Fibrin

Leukoctye Platelet Rich Fibrin (L-PRF) is a by-product of blood (plasma) that is rich in platelets. Until now, its use has been confined to the hospital setting. This was due mainly to the cost of separating the platelets from the blood and the large amount of blood needed to produce a suitable quantity of platelets. New technology permits doctors to harvest and produce a sufficient quantity of platelets from only 55 cc of blood, which is drawn from the patient while they are having outpatient surgery.

Why All The Excitement About L-PRF?

L-PRF permits the body to take advantage of the normal healing pathways at a greatly accelerated rate. During the healing process, the body rushes many cells and cell-types to the wound in order to initiate the healing process. One of those cell types is platelets. Platelets perform many functions, including formation of a blood clot and release of growth factors (GF) into the wound. These growth factors; platelet derived growth factors (PDGF), transforming growth factor beta (TGF), and insulin-like growth factor (ILGF), function to assist the body in repairing itself by stimulating stem cells to regenerate new tissue. The more growth factors released and sequestered into the wound, the more stem cells are stimulated to produce new tissue. Thus, L-PRF permits the body to heal faster and more efficiently.

A subfamily of TGF, is bone morphogenic protein (BMP). BMP has been shown to induce the formation of new bone in research studies in both animals and humans. This is of great significance to the surgeon who places dental implants. By adding L-PRF, and BMP, to the implant site with bone substitute particles, the implant surgeon can now grow bone more predictably and faster than ever before.

L-PRF Has Many Clinical Applications

L-PRF can be used to aid Bone grafting for dental implants. This includes onlay and inlay grafts, sinus lift procedures, ridge augmentation procedures, closure of cleft and/or lip, and palate defects. It can also assist in repair of bone defects created by removal of teeth, or small cysts and repair of fistulas between the sinus cavity and mouth.

L-PRF Also Has Many Advantages

Safety: L-PRF is a by-product of the patient’s own blood, therefore, disease transmission is not an issue.

Convenience: L-PRF can be generated in the doctor’s office while the patient is undergoing an outpatient surgical procedure such as the placement of dental implants.

Faster healing: The supersaturation of the wound with L-PRF, and thus growth factors, produces an increase of tissue synthesis and faster tissue regeneration.

Cost effectiveness: Since L-PRF harvesting is done with only 55 cc of blood in the doctor’s office, the patient need not incur the expense of the harvesting procedure in hospital or at a blood bank.

Ease of use: L-PRF is easy to handle and actually improves the ease of application of bone substitute materials and bone grafting products by making them more gel-like.

Frequently Asked Questions About L-PRF

Is L-PRF safe? Yes. During the outpatient surgical procedure a small amount of your own blood is drawn out via the IV. This blood is then placed in the L-PRf centrifuge machine and spun down. In less than 15 minutes, the L-PRF is formed and ready to use.

Should L-PRF be used in all bone-grafting cases? Not always. In some cases, there is no need for L-PRF. However, in the majority of cases, application of L-PRF to the graft will increase the final amount of bone present, in addition to making the wound heal faster and more efficiently.

Will my insurance cover the costs? Unfortunately not. The cost of the L-PRF application (approximately $200) is paid by the patient.  It is significantly less expensive, easier to process and more effective than Platelet Rich Plasma (PRP)

Can L-PRF be used alone to stimulate bone formation? No. L-PRF must be mixed with either the patient’s own bone, a bone substitute material such as demineralized freeze-dried bone, or a synthetic bone product, such as BIO-OSS.

Are there any contraindications to L-PRF? Very few. Obviously, patients with bleeding disorders or hematologic diseases do not qualify for this in-office procedure. Check with your surgeon and/or primary care physician to determine if PRP is right for you.

Cortland Oral Surgery

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Excellent

- Paul D

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I have had many dentist visits over the years and dental work is not pleasant for the most part. Dr. SanGiacomo is one of the best and the staff is also at the top of the list. I do not live in Cortland and am not familiar with the area, but Dr. was recommended by my dentist and I am very appreciative of that. If I need more work done in the future, I know where to go. Also, the payment was less than the estimate given at time of appointment - always a pleasant surprise. I highly recommend Cortland Oral Surgery Center.

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Good experience

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Overall good experience. I was extremely stressed about it and the staff was very friendly which made me feel better.

- India S

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I'm very pleased with the procedure. My only complaint is that the armrests are not sufficiently long enough for proper white knuckling! Although I plan not to be a regular, should I require oral surgery in the future, I'd call you folks first.

- Michael V

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Great services and staff is very friendly.

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Very professional

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Although I had some nerves before the surgery, I felt very comfortable because I was in such caring hands between the doctor and the nurses in the office. I’m so appreciative of how they treated me.

- Katherine M

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Pulling teeth is never a fun thing, but thanks to the friendly and professional staff it turns into something that is easier to deal with. My greatest appreciation to Dr. SanGiacomo and the Practice staff for the great experience. Thank You.

- Dorothy C

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Quick, relatively painless. Doctor definitely eased the tension. Didn’t push me when I started gagging. Assistants were extremely nice, routinely checking on me to makes sure I was comfortable and ok. Was as pleasant experience as it could be, all things considered.

- Timothy L

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Cortland Oral Surgery is a fantastic place of business, very clean and professional. The entire staff is very patient and friendly and completely thorough with paperwork for patients' history, needs, and insurance reimbursements. They tackle any concerns you may have before, during, and after the procedures and always with smiles. Wonderful place to take kids and teenagers for oral care!

- Kristin K

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Would like to thank everyone for my care.. I was in pain and they without hesitation asked me to come back and they dealt with me kinda freaking out. Couldn’t ask for a better person in that situation

- Seth W

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Best oral surgeon ever!

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Tooth extraction went as well as I possibly could have hoped for.

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Great experience, no pain and friendliness of staff was wonderful

- Maria W

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very good

- s f

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Will be back again - recommended him to my wife

- Jeffrey N

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Was so nervous about having tooth pulled but I never felt a thing, just a few pricks from the needle used to numb me up! Well done!

- Tama S

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They did an amazing job!

- Amber C

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I was very nervous but Dr and staff were awesome and very informative. Thank you

- Helena W

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