Leukocyte Platelet Rich Fibrin

Leukoctye Platelet Rich Fibrin (L-PRF) is a by-product of blood (plasma) that is rich in platelets. Until now, its use has been confined to the hospital setting. This was due mainly to the cost of separating the platelets from the blood and the large amount of blood needed to produce a suitable quantity of platelets. New technology permits doctors to harvest and produce a sufficient quantity of platelets from only 55 cc of blood, which is drawn from the patient while they are having outpatient surgery.

Why All The Excitement About L-PRF?

L-PRF permits the body to take advantage of the normal healing pathways at a greatly accelerated rate. During the healing process, the body rushes many cells and cell-types to the wound in order to initiate the healing process. One of those cell types is platelets. Platelets perform many functions, including formation of a blood clot and release of growth factors (GF) into the wound. These growth factors; platelet derived growth factors (PDGF), transforming growth factor beta (TGF), and insulin-like growth factor (ILGF), function to assist the body in repairing itself by stimulating stem cells to regenerate new tissue. The more growth factors released and sequestered into the wound, the more stem cells are stimulated to produce new tissue. Thus, L-PRF permits the body to heal faster and more efficiently.

A subfamily of TGF, is bone morphogenic protein (BMP). BMP has been shown to induce the formation of new bone in research studies in both animals and humans. This is of great significance to the surgeon who places dental implants. By adding L-PRF, and BMP, to the implant site with bone substitute particles, the implant surgeon can now grow bone more predictably and faster than ever before.

L-PRF Has Many Clinical Applications

L-PRF can be used to aid Bone grafting for dental implants. This includes onlay and inlay grafts, sinus lift procedures, ridge augmentation procedures, closure of cleft and/or lip, and palate defects. It can also assist in repair of bone defects created by removal of teeth, or small cysts and repair of fistulas between the sinus cavity and mouth.

L-PRF Also Has Many Advantages

Safety: L-PRF is a by-product of the patient’s own blood, therefore, disease transmission is not an issue.

Convenience: L-PRF can be generated in the doctor’s office while the patient is undergoing an outpatient surgical procedure such as the placement of dental implants.

Faster healing: The supersaturation of the wound with L-PRF, and thus growth factors, produces an increase of tissue synthesis and faster tissue regeneration.

Cost effectiveness: Since L-PRF harvesting is done with only 55 cc of blood in the doctor’s office, the patient need not incur the expense of the harvesting procedure in hospital or at a blood bank.

Ease of use: L-PRF is easy to handle and actually improves the ease of application of bone substitute materials and bone grafting products by making them more gel-like.

Frequently Asked Questions About L-PRF

Is L-PRF safe? Yes. During the outpatient surgical procedure a small amount of your own blood is drawn out via the IV. This blood is then placed in the L-PRf centrifuge machine and spun down. In less than 15 minutes, the L-PRF is formed and ready to use.

Should L-PRF be used in all bone-grafting cases? Not always. In some cases, there is no need for L-PRF. However, in the majority of cases, application of L-PRF to the graft will increase the final amount of bone present, in addition to making the wound heal faster and more efficiently.

Will my insurance cover the costs? Unfortunately not. The cost of the L-PRF application (approximately $200) is paid by the patient.  It is significantly less expensive, easier to process and more effective than Platelet Rich Plasma (PRP)

Can L-PRF be used alone to stimulate bone formation? No. L-PRF must be mixed with either the patient’s own bone, a bone substitute material such as demineralized freeze-dried bone, or a synthetic bone product, such as BIO-OSS.

Are there any contraindications to L-PRF? Very few. Obviously, patients with bleeding disorders or hematologic diseases do not qualify for this in-office procedure. Check with your surgeon and/or primary care physician to determine if PRP is right for you.

Cortland Oral Surgery

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The staff was very pleasant and good at their work. The doctor was very caring and removed my tooth quickly and with very little pain. I am very happy with the outcome.

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Great job team!

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Very easy procedure...great doctor and nurse!

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I am so satisfied with Dr. San Giacomo, that I don't believe I will ever go anywhere else for oral surgery. Thank you to all who cared for me during my surgery and after-care!

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Excellent service. Good staff.

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I’ve had two procedures and would definitely come back to Cortland Oral Surgery for any other needs I had of this nature.

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Friendly and relaxing. Was very comfortable and relaxed for the procedure

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The staff and Dr. were professional and courteous. Quick in and out pain free extraction. Overall great office

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Fast procedure

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was easy

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Scheduled quickly to remove a cracked tooth. The procedure went well with a follow up visit the next week.

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Great Staff and Doctor. I had 2 teeth pulled They explained each detail before extraction and during the process. I was very impressed.

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I was very happy with the service we received. I would recommend this office to others.

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Upon call to have a tooth extracted I received a appointment that week and a time that worked for me. I used the on line site to fill out the paper work so to speed up everything upon my arrival. The dr. and his assistant made me feel comfortable answered all my question and kept informed all through the procedure. After the procedure the assistant went over what I should expected and do now that the tooth was removed. I also received a hand out what she had gone over and said if I had any questions to call. The over all experience went smooth and the Dr. and staff were great.

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I would and will recommend you to anyone needing an oral surgeon.

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I was extremely happy with my experience in your office. Dr. SanGiacomo and his staff were excellent in terms of efficiency, courtesy and kindness. The procedure was flawless and pain free. I was expecting to awake the next day in pain, yet I was surprised to wake with little to no pain and no need to take any pain medication. Thank you all. Paul

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It was a great experience! Nobody likes the dentist but this office really made it comfortable, easy, and fast! The doctor/dentist was GREAT!!

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The visit was Great! When I called the day before and made appt. It was for 3:30 the next day and after filling out information on line for my appt. The receptionist called me back and was able to get me in that next morning at 8:30 instead! I was in alot of pain and my face was swellon. I was scared and the Dr was joking around with me and it helped me loosen up! Thank you for that!!

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I think I said it all love the quick service !!

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