Leukocyte Platelet Rich Fibrin

Leukoctye Platelet Rich Fibrin (L-PRF) is a by-product of blood (plasma) that is rich in platelets. Until now, its use has been confined to the hospital setting. This was due mainly to the cost of separating the platelets from the blood and the large amount of blood needed to produce a suitable quantity of platelets. New technology permits doctors to harvest and produce a sufficient quantity of platelets from only 55 cc of blood, which is drawn from the patient while they are having outpatient surgery.

Why All The Excitement About L-PRF?

L-PRF permits the body to take advantage of the normal healing pathways at a greatly accelerated rate. During the healing process, the body rushes many cells and cell-types to the wound in order to initiate the healing process. One of those cell types is platelets. Platelets perform many functions, including formation of a blood clot and release of growth factors (GF) into the wound. These growth factors; platelet derived growth factors (PDGF), transforming growth factor beta (TGF), and insulin-like growth factor (ILGF), function to assist the body in repairing itself by stimulating stem cells to regenerate new tissue. The more growth factors released and sequestered into the wound, the more stem cells are stimulated to produce new tissue. Thus, L-PRF permits the body to heal faster and more efficiently.

A subfamily of TGF, is bone morphogenic protein (BMP). BMP has been shown to induce the formation of new bone in research studies in both animals and humans. This is of great significance to the surgeon who places dental implants. By adding L-PRF, and BMP, to the implant site with bone substitute particles, the implant surgeon can now grow bone more predictably and faster than ever before.

L-PRF Has Many Clinical Applications

L-PRF can be used to aid Bone grafting for dental implants. This includes onlay and inlay grafts, sinus lift procedures, ridge augmentation procedures, closure of cleft and/or lip, and palate defects. It can also assist in repair of bone defects created by removal of teeth, or small cysts and repair of fistulas between the sinus cavity and mouth.

L-PRF Also Has Many Advantages

Safety: L-PRF is a by-product of the patient’s own blood, therefore, disease transmission is not an issue.

Convenience: L-PRF can be generated in the doctor’s office while the patient is undergoing an outpatient surgical procedure such as the placement of dental implants.

Faster healing: The supersaturation of the wound with L-PRF, and thus growth factors, produces an increase of tissue synthesis and faster tissue regeneration.

Cost effectiveness: Since L-PRF harvesting is done with only 55 cc of blood in the doctor’s office, the patient need not incur the expense of the harvesting procedure in hospital or at a blood bank.

Ease of use: L-PRF is easy to handle and actually improves the ease of application of bone substitute materials and bone grafting products by making them more gel-like.

Frequently Asked Questions About L-PRF

Is L-PRF safe? Yes. During the outpatient surgical procedure a small amount of your own blood is drawn out via the IV. This blood is then placed in the L-PRf centrifuge machine and spun down. In less than 15 minutes, the L-PRF is formed and ready to use.

Should L-PRF be used in all bone-grafting cases? Not always. In some cases, there is no need for L-PRF. However, in the majority of cases, application of L-PRF to the graft will increase the final amount of bone present, in addition to making the wound heal faster and more efficiently.

Will my insurance cover the costs? Unfortunately not. The cost of the L-PRF application (approximately $200) is paid by the patient.  It is significantly less expensive, easier to process and more effective than Platelet Rich Plasma (PRP)

Can L-PRF be used alone to stimulate bone formation? No. L-PRF must be mixed with either the patient’s own bone, a bone substitute material such as demineralized freeze-dried bone, or a synthetic bone product, such as BIO-OSS.

Are there any contraindications to L-PRF? Very few. Obviously, patients with bleeding disorders or hematologic diseases do not qualify for this in-office procedure. Check with your surgeon and/or primary care physician to determine if PRP is right for you.

Cortland Oral Surgery

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Had all 4 wisdom teeth removed yesterday and it was painless! I was not sedated and only general anesthesia was used. Overall I would recommend this Dr and Staff to anyone needed and surgical dental care.

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Professional, friendly, and down to earth. Explained what was going on through the process. Made sure I was comfortable.

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Dr. SanGiacomo and his staff put my daughter completely at ease. Our experience was terrific. We would definitely return.

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Doc was very patient with difficult extraction. Explained why difficult and showed me evidence. Assistant was sweet and supportive, had good teamwork with Dr San Giacomo.

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Putting your trust in a Doctor and their practice takes a lot for me to do. I would revisit the Dr. for anything related to this type of need, he is a true professional with an impeccable demeanor and by the way he has a slight sense of humor! Totally a GOOD experience, Thanks Doc S. and your staff for going above and beyond the call for me!

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Procedure described clearly. Professional and friendly.

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Wonderful experience, which sounds very strange for a tooth extraction, I was really scared, and the doctor and staff were wonderful, very professional, very patient and caring. Procedure was very quick and I was done before I had a chance to panic.

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Courteous, friendly and professional...I never felt rushed and was well cared for start to finish.

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I was there for consultation on a tooth problem. The doctor and the staff were all wonderful - professional, friendly, caring, explained everything very thoroughly for me. I'd most certainly go back if ever need be.

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I had a wonderful experience throughout my oral surgery procedure. Staff was friendly and welcoming and the doctor put me at ease, thoroughly explaining options and answering all of my questions. I was kept very comfortable throughout the entire process and felt I was in excellent hands.

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everything was very professional

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what a great office - these folks have a genuine feeling of family - very rare these days - and Dr. San Giacomo is simply the best, most skilled oral surgeon in our part of Upstate NY - he is amazingly focused and patient, and great to communicate with - after my experience with Dr. San Giacomo and his staff, i would never consider seeing another oral surgeon....it's just that simple:

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Great job by all

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The office was clean and orderly. The procedure was done within a timely manner once started.

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